Superoxide Dismutase Hypertrophy of Cerebral Arterioles in Mice Deficient in Expression of the Gene for CuZn
نویسندگان
چکیده
Superoxide Dismutase Hypertrophy of Cerebral Arterioles in Mice Deficient in Expression of the Gene for CuZn Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2006 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.0000227236.84546.5a 2006;37:1850-1855; originally published online June 8, 2006; Stroke. http://stroke.ahajournals.org/content/37/7/1850 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase.
BACKGROUND AND PURPOSE Reactive oxygen species are believed to be an important determinant of vascular growth. We examined effects of genetic deficiency of copper-zinc superoxide dismutase (CuZnSOD; SOD1) on structure and function of cerebral arterioles. METHODS Systemic arterial pressure (SAP) and cross-sectional area of the vessel wall (CSA) and superoxide (O2-) levels (relative fluorescenc...
متن کاملP16: Effect of Hesperetin Nanoparticles on Cerebral Gene Expression and Activity of Catalase and Superoxide Dismutase in Alzheimer’s Rat
Hesperetin (Hst) is a well-known bioflavonoid, has low bioavailability. Hesperetin nanoparticles (Nano-Hst) enhance its bioavailability. Nano-Hst were not explored for their potential therapeutic activities in Alzheimer’s disease (AD). Hence, the present study was performed to evaluate the protective effect of Nano-Hst in comparison to free Hesperetin on against intracerebroventricular in...
متن کاملTransgenic CuZn-superoxide dismutase inhibits NO synthase induction in experimental subarachnoid hemorrhage.
BACKGROUND AND PURPOSE The expression of inducible NO synthase (iNOS) after experimental subarachnoid hemorrhage (SAH) has been postulated to play a critical role in the pathogenesis of SAH and subsequent cerebral vasospasm. The inhibitory effect of CuZn-superoxide dismutase (CuZn-SOD) on the induction of iNOS after SAH was examined by using transgenic mice overexpressing CuZn-SOD. METHODS SO...
متن کاملDeficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia
There is an emerging consensus that hyperhomocysteinemia is an independent risk factor for cerebral vascular disease and that homocysteine-lowering therapy protects from ischemic stroke. However, the mechanisms by which hyperhomocysteinemia produces abnormalities of cerebral vascular structure and function remain largely undefined. Our objective in this study was to define the mechanistic role ...
متن کاملEnhancement of Solubility and Specific Activity of a Cu/Zn Superoxide Dismutase by Co-expression with a Copper Chaperone in Escherichia coli
Background: Human Cu/Zn superoxide dismutase (hSOD1) is an antioxidant enzyme with potential as a therapeutic agent. However, heterologous expression of hSOD1 has remained an issue due to Cu2+ insufficiency at protein active site, leading to low solubility and enzymatic activity.Objectives:The effect of co-expressed human copper chaperone (hCCS) to enhance the solubility and enzymatic act...
متن کامل